Efficacy of Diltiazem in the Treatment of Chronic Anal Fissure: An Overview

Opening of the article

Anal fissure is a common medical problem which effect both sexes equally. Until recently the gold standard treatment for chronic anal fissure was surgical lateral internal spincterotomy but recently chemical spinteractomy has become popular in the surgical practice. In the treatment of chronic anal fissure Ca2+ channel blockers play an important role which was proved to be efficacious in various clinical trials. Mechanism involved in these drugs supposed to be due to vasodilatation at the fissure site and hence it increases local blood circulation leads to enhance healing.