Why Diabetic Foot Ulcers do not heal?

Opening of the article

Diabetic foot ulcers are known for their chronicity and they pose challenges to even the most experienced health care professionals. Three basic reasons of chronicity of Diabetic Foot Ulcers are Diabetic Triopathy (neuropathy, vasculopathy & immunopathy),inadequate levels of growth factors & presence of biofilm. Following an injury to the skin, a set of complex biochemical events take place in a closely orchestrated cascade in order to repair the damage. The natural healing process can be divided into four stages: inflammation, granulation, epithelialisation and maturation.