Original Article · pages 79–83
Association of eNOS promotor region polymorphism T-786C and its mRNA expression in Primary Open Angle Glaucoma
Cite this article
Janani Ramesh, Roshnara P. P, Siddharth Madan, Ekta Debnath, Anju Jain, Rajiv Garg. Association of eNOS promotor region polymorphism T-786C and its mRNA expression in Primary Open Angle Glaucoma. J Int Med Sci Acad. 2024;37(2):79–83.
Opening of the article
Background: Primary Open Angle Glaucoma (POAG) is a progressive degenerative disease affecting the retinal ganglion cells. T-786C, single nucleotide polymorphism (SNP) in the promotor region of endothelial nitric oxide synthase gene ( eNOS) where thymine is replaced by cytosine at -786 is associated with impaired shear stress inducibility of the eNOS expression. Pathophysiology of glaucoma and its association with eNOS is ambiguous which warrants for further study. Objective: To examine the association between T- 786C polymorphism in eNOS gene and its mRNA expression in Primary Open Angle Glaucoma.
Keywords
Primary Open angle Glaucoma, Nitric Oxide, Single Nucleotide Polymorphism, ELISA, real time PCR. 80 J Int Med Sci Acad 2024, (April-June), Vol 37