A Single-masked, Randomized, Controlled Trial of Ginger Extract in the Treatment of Nausea and Vomiting of Pregnancy

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In order to evaluate the efficacy and tolerability of an oral ginger extract formulation in comparison to oral fixed dose combination of doxylamine 10 mg plus pyridoxine 10 mg, seventy eight (78) women between 6-16 weeks of pregnancy, complaining of nausea and vomiting (NVP), were randomized to receive either ginger formulation or pyridoxine-doxylamine preparation in a single blind fashion. Efficacy variables were the severity of nausea and vomiting scored by visual analog scale, on the day of each visit, as well as averaged over the past week; the average number of nausea spells or vomiting episodes per day over the past week; and subjective well-being assessed as a binary variable.