Editorial · pages 171–174
Matrix Metalloproteinase-2 and its Relation with Incisional & Inguinal Hernia. - -Vinod Jain, Rohit Srivastava, Nagendra Singh Rawat, Samir Misra, Shweta Jha, DV Amla
Cite this article
Matrix Metalloproteinase-2 and its Relation with Incisional & Inguinal Hernia. - -Vinod Jain, Rohit Srivastava, Nagendra Singh Rawat, Samir Misra, Shweta Jha, DV Amla. J Int Med Sci Acad. 2011;24(4):171–174.
Opening of the article
Abnormal collagen metabolism is thought to play an important role in the development of primary inguinal and ventral hernia. The detection of an impaired collagen balance both in the tissue as well as in cultured fibroblasts underlines the suspicion that the development of hernia is likely to be implemented primarily by a disturbance of the fibroblast function and their collagen genes. Based on these results we assume that the altered collagen synthesis in hernia patients can be regarded as a genetically linked deregulation serving as a basic initiating or promoting factor for the development of primary inguinal hernias.
Keywords
MMP-2, Matrix Metalloproteinase-2, inguinal hernia, DAC-ELISA, collagen metabolism, PBST- Phosphate Buffer Saline Tween-20, Incisional hernia Correspondence: Dr. Vinod Jain, Assistant Professor